Articles

Consistency Analysis of Genomic Alterations Between Tumor Tissue and Circulating Cell-Free DNA in Untreated Lung Adenocarcinoma in Southern Jiangsu Region of China

Research Article   Open Access
With the increasing mortality, lung adenocarcinoma has become the most common cancer and the leading cause of cancer-related death in China [1]. According to histology type, over 85% lung adenocarcinoma patients were classified into Non-Small Cell Lung Cancer (NSCLC). And more than 70% of them were in advanced stage when firstly diagnosed, and then accompanied ..

Chronic Stress in Epithelial Ovarian Cancer: Mechanisms and Impact

Research Article   Open Access
Epithelial Ovarian Cancer (EOC) a major cause of cancer-related mortality among women worldwide. Although substantial progress has been made in cytoreductive surgery, platinum-based chemotherapy, targeted therapies, and immunotherapeutic strategies, long-term survival remains limited because many patients present with advanced-stage ..

Breast Cancer Characteristics Among World Trade Center-Exposed Survivors

Research Article   Open Access
The question of an increased cancer risk has been raised in rescue and recovery workers and local community members (local workers, residents, commuters, students) who were exposed to a complex mixture of known and suspected carcinogens after the destruction and collapse of the World Trade ..

Assessment of Knowledge, Attitude, and Practice Regarding Human Papillomavirus (HPV) Vaccination Among Nursing Officers in a Tertiary Government Cancer Hospital

Research Article   Open Access
Cervical cancer is largely attributable to persistent high-risk Human Papillomavirus (HPV) infection and is preventable through HPV vaccination. Nursing officers are frontline health educators whose knowledge, attitudes, and personal practices can influence vaccine acceptance in the community. This study assessed knowledge, attitude ..

Weekly Mobile Health Engagement and Physical Activity in Cancer Survivors

Research Article   Open Access
Advances in cancer detection and treatment have resulted in a rapidly growing population of cancer survivors, shifting the focus of cancer care beyond survival toward optimizing long-term health, physical functioning, and psychological well-being. Although cancer mortality continues to decline, many cancer survivors continue to experience persistent ..

Relationship Between Two Key Non-Coding RNAS in Breast Cancer: HOTAIR and miR-331-3p

Research Article   Open Access
Breast Cancer (BC) is the most common cancer type among women; although the cancer is not limited to females, it is rarely seen in men (only 0.5-1% of breast cancers are found in men) [1]. In Iran, based on the GLOBALCAN 2020 report, breast cancer was recognized as the most abundant type

RAS and PI3K Driver Mutations in Metastatic Colorectal Cancer: A Cohort Study of 60 Patients

Research Article   Open Access
Colorectal Cancer (CRC) is the third most common malignancy worldwide, with metastatic disease (MCRC) accounting for a significant proportion of cases [1]. The management of mCRC has shifted toward precision oncology, driven by the identification of predictive biomarkers [2]. Among these, RAS gene

Influence of Reproductive Factors on Breast Cancer Outcomes in Premenopausal Women

Research Article   Open Access
The incidence of breast cancer in young, premenopausal women has been steadily increasing since the 2000s. Surveillance, Epidemiology, and End Results (SEER) program data from 2019-2022 demonstrated an annual breast cancer incidence rate of 24-25 per 100,000 in women under 40. The rates vary across

Androgen Receptor as a Prognostic and Predictive Factor for Response to Trastuzumab Among Female Patients with Invasive HER2-Positive Breast Cancer

Research Article   Open Access
Breast cancers overexpressing Human Epidermal growth factor Receptor-2 (HER2) have relatively poor outcome. Androgen receptor in breast cancer was studied and showed different prognostic data among the different molecular breast cancer subtypes.

Cardiac Safety of Trastuzumab Deruxtecan in HER2-Positive Metastatic Breast Cancer: A One-Year Prospective Echocardiographic Study

Research Article   Open Access
Trastuzumab Deruxtecan (T-DXd) is a novel antibody–drug conjugate with proven efficacy in HER2-positive metastatic breast cancer. While its safety profile is generally favorable, data on cardiotoxicity remains limited.

Functional Consequences of Inhibition of Histone H3 Citrullination in Neutrophils

Research Article   Open Access
Neutrophils play a dual role in oncology, where they can either support anti‑tumor immunity or, in their tumor‑associated form, promote cancer progression through immunosuppression and angiogenesis. Their abundance and phenotype in the tumor microenvironment

MRI-Guided Percutaneous Cryoablation of Hepatic Tumors in Pericardiac Locations: A Case Series

Research Article   Open Access
Percutaneous ablation of hepatic tumors in pericardiac locations poses a recognized technical challenge due to limited acoustic windows, proximity to the myocardium and phrenic nerve, and risk of non-target thermal injury. MRI guidance

Breast Cancer, Non-Selective Transient Receptor Potential (TRP) Cation channels, and Antimicrobial Peptides: A Search for Potential Cancer Targets

Review Article   Open Access
Breast Cancer (BC) is one of the most common types of cancer in women throughout the world. However, it is now recognized that there exists new and improved therapeutic treatments and modalities for this devastating disease in women.

Comparative Study Between Gemcitabine Plus Cisplatin and Docetaxel Plus Fluorouracil Plus Cisplatin as Induction Chemotherapy in Unresectable Locally Advanced Head and Neck Cancer Patients in Terms of PFS and OS at 1 Year Follow Up

Research Article   Open Access
Head and Neck Squamous Cell Carcinoma (HNSCC) represents a major global health burden, accounting for approximately 800,000 new cases and 330,000 deaths annually. A substantial proportion of patients present with Locally Advanced Disease (LAHNSCC).

Increasing Intra-Lesional pH with the Use of Bicarbonate Along with Doxorubicin in Trans-Arterial Chemoembolization of Hepatocellular Carcinoma: Pilot Study

Research Article   Open Access
Doxorubicin is a weakly basic agent and undergoes protonation below a pH of 7. The effectiveness of doxorubicin may be greatly diminished in an acidic environment, which is common in hepatocellular carcinomas during the trans arterial embolization process.

Androgen Receptor and its Prognostic Correlation with Age and Menopausal Status Among Female Patients with Invasive Breast Cancer

Research Article   Open Access
High AR expression often correlates with postmenopausal status and increasing age. Obesity and weight gain are associated with increased risk of postmenopausal breast cancer, with AR potentially driving tumor progression in these environments.

The Anti-Cancer Effects of Mustard Oil Through the Targeting of Oncoprotein Transcription Factors in Colon Cancer Cells

Research Article   Open Access
Colon cancer, which originates in the large intestine (colon), is often aggressive due to late-stage diagnoses, resulting in poor prognosis and high mortality rates. In this study, we explore the biological functions and potential anticancer effects of several natural oils, including camphor oil, mustard oil, and rosemary oil, in colon cancer Caco-2 cells.

Preoperative Prediction of Macro Trabecular-Massive Hepatocellular Carcinoma: Value of Ultrasound and Contrast-Enhanced Ultrasound

Research Article   Open Access
The objective of this study was to develop and validate a predictive model for MTMHCC by integrating preoperative Ultrasound (US) and Contrast-Enhanced Ultrasound (CEUS) features with relevant clinical characteristics.

Biological and Molecular Aspects of Endometrial Cancer

Review Article   Open Access
The importance of the topic is conditioned by the high level of morbidity due to Endometrial Cancer (EC), constituting a major problem with global impact in public health. Endometrial cancer represents 4.8% of the cases of malignant tumors and ranks, worldwide, on the 6th place in the structure of the incidence of malignant tumors in women [1,2].

The Multifaceted Role of Neutrophil Extracellular Traps in Pancreatic Cancer: From Pathogenesis to Therapeutic Implications

Review Article   Open Access
Neutrophil Extracellular Traps (NETs) have emerged as central regulators of Pancreatic Ductal Adenocarcinoma (PDAC) progression, serving as a mechanistic nexus linking inflammation, fibrosis, immunosuppression, and thrombosis. In PDAC, NETs are hyperactivated through multiple pathways, including the CXCL8-CXCR2 axis and Reactive Oxygen Species (ROS) signaling.

Coalescing Molecular Testing and Clinical Insights in MSH2 Positive Lynch Syndrome with Complete Immunotherapy Response

Case Report   Open Access
Lynch Syndrome, genetic predisposition syndrome is a hereditary cause of defective microsatellite instability (MSH2, MLH1, MSH6, PMS2, EPCAM) with an increased life time risk of malignancies in different organs. Prostate cancer has an accumulate risk of diagnosis in 12.8% of cases.

Incidence of Radiation-Induced Hypopituitarism in Pediatric and Young Adult Patients Treated for Primary Intracranial Tumors

Research Article   Open Access
Radiotherapy (RT) remains an integral component in the management of primary intracranial tumors. However, incidental radiation exposure to the hypothalamic–pituitary axis may result in endocrine dysfunction, particularly in pediatric and young adult patients.

Co-relation of Educational Status and Cancer Stage at the Time of Diagnosis: Experience of a Tertiary Care Center in India

Research Article   Open Access
The cancer burden in India is drastically increasing [1]. Many patients present in advanced stage at the time of diagnosis, due to undue delay in seeking medical attention. There are various factors which may result in delayed patient presentation

Breaking Ground in Oncology; Enteromix and the Future of Personalized Cancer Vaccination

Review Article   Open Access
The field of oncology is undergoing a paradigm shift towards immunotherapies, with therapeutic cancer vaccines emerging as a promising frontier. Against a backdrop of global innovation, particularly in messenger RNA (mRNA) technology, Russia has announced significant progress in its national cancer vaccine programs.

Assessment of Patient Satisfaction in the Outpatients’Chemotherapy Unit of Chandaria Cancer Center, MTRH, Kenya

Research Article   Open Access
Cancer remains a major cause of morbidity and mortality globally. Chemotherapy, while essential in cancer management, has profound physical and psychological implications that can affect patients’ Quality of Life (QoL) and satisfaction.

Stratified Approach to the Correction of Sarcopenia in Oncological Patients Depending on its Severity

Research Article   Open Access
Sarcopenia, characterized by the progressive loss of skeletal muscle mass and strength, has emerged as a critical clinical problem in oncology. In recent years, it has been recognized not only as a manifestation of cancer cachexia.

Androgen Receptor as a Prognostic and Predictive Factor for Response to Aromatase Inhibitors Among Female Patients with Invasive Luminal A Breast Cancer

Research Article   Open Access
Estrogen receptor score of expression is an important predictive and prognostic marker in luminal A invasive breast cancer. Androgen receptor in breast cancer was studied and showed different prognostic data among the different populations.

Lesson Learned from Launching India’s First Indigenous CAR-T Cell Therapy

Review Article   Open Access
Chimeric Antigen Receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed and refractory hematological malignancies worldwide. However, the clinical and commercial availability of these therapies has been largely restricted to high-income Countries (HICs).

Genetic Profiling of 717 Colorectal Cancer Patients: North Macedonian Study

Research Article   Open Access
Colorectal Cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cancer death worldwide. In last two decades, significant improvements have been made in Response Rates (RR), Progression-Free Survival (PFS).

Genetic Alterations Profiling in North Macedonian Lung Cancer Patients

Research Article   Open Access
Late diagnosis and inapropriately efficient treatment regimens of lung cancers lead to poor prognosis with 5-year survival rate of 22% for lung cancers in general (Non-Small Cell Lung Cancer (NSCLC) 26% and Small Cell Lung Carcinoma (SCLC) 7%).

The Prognostic and Predictive Value of Inflammatory Markers in Elderly Breast Cancer Women

Research Article   Open Access
The prognostic and predictive value of inflammatory markers in breast cancer is known. However, the relationship in elderly patients has rarely been reported. This study aimed to explore the connection between pretreatment inflammatory markers and the survival of patients with stage I–III elderly breast cancer.

Microsatellite Instability (MSI) and Mismatch Repair (MMR) Protein in Gastric Cancer Patients: Clinical Significance

Research Article   Open Access
To investigate the expression characteristics of Microsatellite Instability (MSI) and Mismatch Repair (MMR) protein in gastric cancer, analyze their correlation with clinicopathological parameters, prognosis, and response to immunotherapy, and provide a basis for individualized treatment of gastric cancer.

A Case Report of a Genetically Related Neuroendocrine Tumor due to a Mutation in the MEN1 Gene

Case Report   Open Access
Multiple endocrine neoplasia type 1, or MEN1 for short, is typically characterized by the simultaneous presence of abnormal conditions in two or more endocrine glands. This article reports a case of MEN1 gene mutation.

Comparative Study of CDK4/6 Inhibitors in Combination with Endocrine Therapy vs. Endocrine Therapy Alone for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Retrospective Study in Egypt

Research Article   Open Access
Endocrine therapy provides the cornerstone for treating estrogen receptor-positive breast cancer, but certain tumors have intrinsic resistance, and developed resistance to hormone treatment is unavoidable in metastatic illness.

A Step Forward Improving the Rational Antimicrobial Management in Pediatric Patients with Cancer: Tackling the Gaps

Review Article   Open Access
Childhood cancer is a significant global health issue, affecting around 300,000 children annually, with survival rates that vary wildly between low-to-middle-income countries and high-income countries. Infections represent one of the main causes of morbidity and mortality in this population.

Rapid and Selective Elimination of Cancer Cells Based on Precision Strategies Targeting the Cell Death Pathways

Review Article   Open Access
Study of type 1/type 2 apoptotic cell death activation elucidates ways to rapid and selective elimination of malignant cells. Optimal activation kinetics in cancer cell apoptosis could change the tumor microenvironment in such a manner that malignant and immunosuppressive in vivo phenotype.

Appendiceal Mucinous Neoplasm (AMN); A Case Series and Literature Review

Case Series   Open Access
Appendiceal Mucinous Neoplasms (AMN) are complex tumors of the appendix that's made up of mucin-producing cells. Histologic differentiation is important, as well-differentiated tumors have a better prognosis. Frequently, appendiceal neoplasm is misdiagnosed because most patients are asymptomatic.

Is it Possible to Predict the Prognosis of Ewing Sarcoma in Adults? Analysis of Clinical Factors and Therapeutic Strategies at a National Sarcoma Treatment Center in Spain

Research Article   Open Access
Ewing Sarcoma (ES) is a malignant neoplasm of primitive neuroectodermal origin, characterized by the t(11;22) (q24;q12) translocation, which generates the EWSR1-FLI1 fusion gene. Although it is the second most common primary bone malignancy in children and adolescents.

The Identification of Genes and Pathways Associated with Cancer-Associated Fibroblasts in Chemotherapy Resistance Provides New Targets for Breast Cancer Therapy

Research Article   Open Access
Cancer-Associated Fibroblasts (CAFs) have been found to play a crucial role in tumor chemoresistance. In this work, we employed silico analyses to identify genes and pathways that affect chemoresistance caused by CAFs in breast cancer.

HTLV-1: A Virus with Oncogenic Potential: Mechanisms, Treatment and Challenges

Review Article   Open Access
More than three decades have passed since Adult T-cell Leukemia/lymphoma (ATL) was first identified as a distinct disease in Japan. During this time, researchers discovered its causative agent the Human T-cell Leukemia virus type 1 (HTLV-1).

Comparing Survival Rates in Patients with Small Cell Lung Carcinoma and Non-Small Cell Lung Carcinoma: A Single-Centre Hospital-Based Study in Indonesia

Research Article   Open Access
This study aimed to compare the survival outcomes of patients with Small-Cell Lung Cancer (SCLC) and Non-Small-Cell Lung Cancer (NSCLC) at Dharmais Cancer Hospital, after adjusting for age, gender, clinical stage, and treatment-related variables.

Clinical Manifestations and Therapeutic Observation of 123 Cases of Basal Cell Carcinoma of the Skin

Research Article   Open Access
From December 2017 to December 2022, the clinical data and surgery of 123 patients with basal cell carcinoma of the skin diagnosed by Chaohu Hospital of Anhui Medical University were retrospectively analyzed to study the clinical characteristics and treatment effects of basal cell carcinoma.

Assessment of Early Outcomes of Radiotherapy in Hepatocellular Carcinoma Patients in Clinical Oncology and Nuclear Medicine Department at Suez Canal University Hospital

Research Article   Open Access
Hepatocellular Carcinoma (HCC) is one of the most common malignancies in the world, particularly in Africa and Asia. Surgical resection and orthotropic liver transplantation are the gold standard therapy, but this treatment option is limited to localized Hepatocellular Carcinoma (HCC) patients.

Quality of Life, Independence, and Support Before and After Surgery with Spinal Cancer

Research Article   Open Access
The spine is the most common site of metastasis of various cancers to the bone, which affects patients' quality of life and independence. The aim of this study was to assess the quality of life, self-efficacy, and social support of patients before and after surgery for spinal cancer, whether it is dependent on the location of the neoplasm and stage.

Intraductal Papillary Neoplasm of Bile Ducts: Report of Two Cases

Case Series   Open Access
IPNB is a rare neoplasia (10-15% of the overall biliary neoplasms), which is a close mimicker as well as precursor of intraductal cholangiocarcinoma. A significant number of patients remain asymptomatic and the disease is incidentally detected during evaluation for unrelated symptoms.

Unveiling the Link to ABC Proteins and Epithelial-Mesenchymal Transition in Cancer

Review Article   Open Access
Cancer is a major global health issue, being the second leading cause of death. Amongst the characteristics observed in cancer cells that contribute for tumor progression and poor prognosis are the acquisition of the Multi-Drug Resistance (MDR) phenotype and the induction of metastasis.

Quality of Life, Independence, Support in Patients Before and After Surgery with Head Cancer

Research Article   Open Access
All over the world we are seeing an increase in cases of head cancer, which affects the quality of life and independence. If we know the health problems before and after surgery, we know that there are headaches, aphasia, epileptic seizures, limb paresis, affecting self-reliance or quality of life.

The Relationship of Molecular Subtypes to Breast Cancer Survival in Arifin Achmad Pekanbaru Hospital, 2014-2023

Research Article   Open Access
Breast cancer is a malignancy of breast tissue originating from the ductal epithelium or its lobules. Its study aims to know characteristics among breast cancer patients in Arifin Achmad hospital from 2017 to 2021.

A Rare Case of Intracranial Germ Cell Tumor in the Elderly: A Case Report

Case Report   Open Access
The vast majority of Germ Cell Tumors (GCT) derive from within the gonads, but a small percentage can arise from extragonadal tissue and are therefore called Extragonadal Germ Cell Tumors (EGCTs) [1]. We report a case of a 74-year-old man with a rapidly developing loss of memory.

DNA Copy Number Variation of Sox4 Fail to Maintain Pluripotency Results to Promote Metastasis in Breast Cancer Patients

Research Article   Open Access
Sox4, early transcription factor and is play an important role during movement of epithelial to mesenchymal transition through invasion and followed by initiation of tumor progression in Breast Cancer (BC) patients. Genetic diversity of stem cell are the unique phenomenon and has been associated with epigenetic modification.

Dynamic Expression Profiles of HMGB1 after BNCT and γ-Irradiation in Cancer Cells

Research Article   Open Access
HMGB1 is known as a DNA-binding protein and present in nucleus. It is involved in chromatin and transcriptional regulation. We previously observed extracellular release of HMGB1 occurs as early responses from cancer cells after Boron Neutron Capture Therapy (BNCT) following 10B-Boronophenylalanine (BPA) administration.

Advanced Life Support in Oncology Intensive Care Units: A Prospective Observational Study

Research Article   Open Access
The survival rate of cancer patients has increased in recent decades, leading to a growing number of admissions to Intensive Care Units (ICUs) and artificial life support, often with questionable indications.

Preservation of Fertility in Patients with Breast Cancer: Literature Review

Review Article   Open Access
Oncofertility is a discipline about the possibility of maintaining reproductive function in patients with malignant tumors. This new medical discipline is based on two main principles – safety and efficiency.

Assessment of Cytotoxicity and Cytokine Expression Pattern of HepG2 Cell Line by Ultra Diluted Hydrastis Canadensis

Research Article   Open Access
The incidence of liver cancer, especially hepatocellular carcinoma, has been increasing at an alarming rate worldwide, which is characterized by poor prognosis, and the treatment of advanced cases is extremely difficult.

Role of Cancer Stem Cells in Failure of T Cell Immunotherapy

Review Article   Open Access
Over the past decade, immunotherapy has emerged as one of the most promising approaches to cancer treatment. Immunotherapy employing Immune-Checkpoint Inhibitors (ICIs), Adoptive Cell Transfer (ACT), Chimeric Antigen Receptor (CAR) - engineered T cells and cancer vaccines, have generated encouraging responses in the treatment of various cancers, and effector anti-tumor T cells.

Comprehensive Analysis Reveals Genomics and Clinical Characteristics of the DNMT Family and TET Enzyme Family in Pan-Cancer

Research Article   Open Access
The purpose of this study is to comprehensively analyse the specific roles of DNA Methyltransferase (DNMT)/Ten-Eleven-Translocation (TET) family genes in pan-cancer. The expression, mutation, Copy Number Variations (CNVs), cancer-related pathways, immune cell infiltration correlation and prognostic potential of DNMT/TET genes were systematically investigated in 33 cancer types using next-generation sequencing data from The Cancer Genome Atlas database.

Molecular Identification and Successful Treatment with Targeted Therapy in Gorlin Syndrome: A Case Report

Case Report   Open Access
Gorlin Syndrome (GS), is a rare autosomal dominant cancer predisposition disorder, frequently under-diagnosed. It is characterized by the presence of multiple Basal Cell Carcinomas (BCCs), odontogenic keratocysts, palmoplantar pits, and many other developmental anomalies and neoplasms.

Resection of Isolated Bilateral Adrenal Metastases from Colorectal Adenocarcinoma

Case Report   Open Access
Bilateral adrenal metastases from colorectal cancer with no extra-adrenal signs of disease is a very rare clinical entity with no established guidelines for management. We describe the unusual clinical treatment course of a 73-year-old male who developed isolated bilateral adrenal metastases within 3 years after resection of a primary rectal adenocarcinoma.

Clinical Case Data Review and Literature Review of Breast Lymphoma

Research Article   Open Access
To investigate the clinical, and pathological features, diagnosis, treatment, and prognosis of Breast Lymphoma (BL). Methods: The general case data of 16 inpatients with breast lymphoma admitted to Liaoning Cancer Hospital from 2014 to 2022 were retrospectively analyzed, and their disease characteristics, treatment and prognosis were analyzed.

Identification of the IncRNA HIF1A-AS3 Biomarker and Analysis of Immune Infiltrates in Breast Cancer

Research Article   Open Access
Breast Cancer (BC) is the predominant malignant tumor among women globally. It has high recurrence which have adverse effects on patient outcomes. Therefore, there is need to identify effective biomarkers for prognostic evaluation.

Artificial Nutrition in Patients undergoing Cytoreductive Surgery and HIPEC

Short Commentary   Open Access
Nutrition's impact on the surgical outcome has been established in various surgical specialties. However, data addressing the nutritional considerations following Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are scarce. We present our experience in nutritional management in our patients underwent CRS+HIPEC.

Unveiling the Promise of Cancer Neoantigens: A New Frontier in Immunotherapy

Review Article   Open Access
Cancer is not only one of the leading causes of mortality and morbidity worldwide, but it is also a large economic burden on the world's population. Tumour heterogeneity restricts the concept of a single drug that can be universally effective against all cancer types.

Development of an Information-Gathering Tool to Support Work Continuity in Cancer Patients Undergoing Outpatient Radiation Therapy

Research Article   Open Access
This study aimed to develop an information-gathering tool to assist cancer patients undergoing outpatient radiation therapy. The tool was designed to help patients and nurses assess symptom management, anticipate treatment-related reactions and social factors, identify concerns early, and support patients in balancing work and treatment.

Recent Advances in Interventional Therapy for Hepatocellular Carcinoma

Review Article   Open Access
Hepatocellular Carcinoma (HCC) is one of the most prevalent and lethal cancers globally. Early diagnosis remains challenging due to the disease's subtle symptoms, often leading to detection at advanced stages with limited treatment options and poor outcomes.

Benefit of Adjuvant Radiotherapy in Parotid Cancer: Single Center Experience

Research Article   Open Access
Observe the benefit of adjuvant radiotherapy in parotid cancer patients in 2 years, regarding the local control and identifying factors of recurrence. The selection of patients was in the Oncology Hospital, XXI Century National Medical in Mexico. The period was from 2013 to 2018, reviewing 129 expedients of patients with parotid cancer who received radiotherapy, finding 52 patients to evaluation for the study.

Audit on the Incidence of Malnutrition in Oncology Patients in South Tipperary General Hospital (STGH)

Short Commentary   Open Access
To first define a cancer patient, a cancer patient is a person who has received a cancer diagnosis who is: going to start treatment or receiving treatment for cancer or symptom management and/ or receiving palliative care [1].

KISS1R Antagonism as a Promising Anti-Cancer Approach: An Overview on Function, Molecular Mechanisms and Therapeutic Potential

Review Article   Open Access
Herein, we explore the Kisspeptin 1 Receptor (KISS1R) as a potential therapeutic target for the restoration of drug sensitivity in Triple-Negative Breast Cancer (TNBC) clinical settings. Recent functional studies of KISS1R have revealed that the receptor plays a pro-metastatic role in TNBC.

Sequential Lineage Switch from B-ALL to AML to MPAL in an Elderly Patient with KMT2A/AFF1 Fusion

Case Report   Open Access
Lineage switch in acute leukemia is rare, often seen in infants and pediatric patients during or after therapy. This report details a unique case in an elderly individual initially diagnosed with Acute B-Lymphoblastic Leukemia (B-ALL) featuring KMT2A/AFF1.

Male Primary Pulmonary Choriocarcinoma with SMARCA4 Deficiency: A Case Report and Literature Review

Case Report   Open Access
We report a rare case of primary pulmonary choriocarcinoma with SMARCA4 deficiency. The patient, a 54-year-old male, had a lesion in the upper lobe of the left lung, identified during a routine physical examination. Pathological examination of the resected specimen revealed a 5.0 cm x 4.5 cm x 3.0 cm tumor.

Impact of the Methodology of Breast Cancer Screening Camps: A Community Based Observational Study

Research Article   Open Access
Breast cancer is a significant health concern globally and early detection remains pivotal for effective treatment. In resource-constrained settings such as India, innovative screening approaches are crucial. This study examines the impact of community-based screening camps versus hospital-based screening within a district-level hospital context, considering accessibility and outreach.

Risk and Predictive Factors of Rate of Lymph Node Invasion in Breast Cancer with Axillary Involvement

Research Article   Open Access
Breast cancer is the most common cancer among women in France. Axillary lymph node invasion has a major prognostic impact. The aim of this study was to evaluate the risk and predictive factors of the rate of lymph node invasion in breast cancer with axillary involvement.

Role of Androgen Receptor in Prostate Cancer: A Brief Update

Review Article   Open Access
Androgen Receptor (AR) is a transcription factor for testosterone and dihydrotestosterone. Prostate cancer cells' survival, growth, and proliferative activity highly depend on a functional AR. The androgen receptor gene is located on chromosome X (Xq11-12) and encodes a 919 amino acid protein with four domains.

Synthesis, Characterization, and Anticancer Activity Studies of the Novel Pyridinyl Zn (II) and Ni (II) Metal Complexes

Research Article   Open Access
Cancer is regarded as one of the «three major killers» threatening human health, and for many years, countless researchers have devoted themselves to researching anticancer agents in the hope of improving the survival rates of cancer patients.

The Importance of Biliary Drainage Catheter Diameter in Malignant Stricture

Research Article   Open Access
Efficacy of 8F and 10F biliary drainage catheters compared in patients with malignant stenosis. Between 2010 and 2012, 106 patients presenting to interventional radiology for malignant biliary obstruction were assessed and 54 patients were included in the study. Liver function tests.

How important is early Disease Detection through Regular Systematic Examinations in People older than 65 Years: An Example of Two Cases

Case Report   Open Access
Early detection of cancer in people over the age of 65 is a key aspect in the fight against this vicious disease. Aging of the body carries with it a number of changes that increase the susceptibility to developing cancer, with greater exposure to risk factors throughout the lifespan.

Primary Frontal Sinus Carcinoma: A Case Report

Case Report   Open Access
Primary frontal sinus carcinoma is rare, with an incidence of 0.3-1% of all paranasal sinus carcinomas. We present an 84-year-old woman who, about a month ago, developed erythema and edema of the skin of the upper eyelids and glabella, accompanied by eye discharge and slight tenderness to touch.

Environmental and Ingestible Toxins: A Review of their Role in the Development of Colon and Rectal Cancer

Review Article   Open Access
In this paper, we review the epidemiological evidence on the relationship between environmental and ingestible toxins and colorectal cancer. We searched PubMed, Embase, and Web of Science for epidemiological studies on environmental and ingestible toxins and colorectal cancer published before June 1, 2022.

Medical Aid in Dying in Pakistan

Mini Review   Open Access
Medical Aid in Dying, or Physician Assisted Suicide, is the practice of hastening the death of those suffering from an incurable disease, such as cancer, or a debilitating disorder, such as amyotrophic lateral sclerosis. It is a practice that is gaining acceptance in many countries around the world.

Efficacy and Safety of Shen Fu Injection Alleviating Chemotherapy-Induced Peripheral Neurotoxicity: A Randomized Controlled Trial

Research Article   Open Access
To analyze the effect of Shenfu injection on Chemotherapy-Induced Peripheral Neuropathy (CIPN) at different stages of tumor chemotherapy. An analysis of 153 patients who were divided into chemotherapy group and combined group was performed chemotherapy within two to six cycles with oxaliplatin or paclitaxel, and combined with or without Shenfu injection.

Recent Advances in Gastrointestinal Neuroendocrine Tumor Classification

Review Article   Open Access
Gastrointestinal Neuroendocrine Tumors (GI-NETs) encompass a broad spectrum of neoplasms arising from neuroendocrine cells, showcasing diverse clinical manifestations and behaviors. The evolution of GI-NET classification has been marked by advancements in histopathology, molecular biology, imaging, and biomarker discovery.

Reversible Toxic Encephalopathy related to Treatment with Capecitabine: A Discussion about Chemotherapy-Induced Neurotoxicity and a Case Report

Case Report   Open Access
Capecitabine is a chemotherapeutic widely used in current medical practice, quickly replacing 5-Fluorouracil in the treatment of certain cancers. Although it is rarely encountered, neurotoxicity is an adverse effect that should not be neglected, especially if elderly patients are involved.

Efficacy of Traditional Chinese Medicine Treatment alone for Recurrent and Refractory Castration-Resistant Prostate Cancer: A Case Report and Literature Review

Case Report   Open Access
Prostate Cancer (PCa) is a malignant tumor that occurs in the epithelial gland of prostate, and it ranks 6th in the incidence rate of malignant tumors among men in China, while the death rate ranks 2nd. The probability of distant metastasis can be as 30 high as 70%, with bone metastasis being the most common.

Thymic Epithelial Tumour Size Reduction after Steroid Therapy without Chemotherapy: A Possible Tumour Treatment? Case Report and Literature Review

Case Report   Open Access
Myasthenia Gravis (MG) is a neuromuscular junction disorder characterised by antibodies directed against postsynaptic antigens (mainly the Acetylcholine Receptors (AChR)). The management of MG symptoms relies on the utilization of anticholinesterases (such as Pyridostigmine), immunosuppressive and immunomodulatory therapies, including therapeutic plasmapheresis or high-dose human immunoglobulin.

Computer-Aided Diagnosis System Based on Deep Learning for Diagnosis of Atypical Endometrial Hyperplasia and Endometrial Cancer on Hysteroscopy

Research Article   Open Access
Hysteroscopy is an effective tool to diagnose and treat abnormal uterine bleeding or uterine cavity abnormalities, especially precancerous or cancerous disorders. In this study, we proposed an Endometrial Cancer (EC) Computer-Aided Diagnosis System (ECCADx) based on deep learning to boost the diagnostic accuracy.

Isolated Breast Sarcoidosis

Case Report   Open Access
Sarcoidosis is a rare non-caseating granulomatous disease of unknown origin that affects multiple systems in the body occurring more frequently in young women age 17-24 years.

RAD6 Overexpression and Ovarian Cancer Chemo-Resistance: Flow Cytometry and Immunohistochemistry

Research Article   Open Access
Ovarian cancer is one of the deadliest women's cancers in the world. Nearly all the patients have poor prognosis and recurrence after standard therapy because of chemo-resistance. The standard therapy is cytoreductive debulking surgery followed by platinum-based chemotherapy.

Oral Tissue Lesions Manifestation in Cancer Patients Following Chemotherapy and Head and Neck Radiation Therapy

Review Article   Open Access
As is known, cancer therapy includes a complex of therapeutic measures: chemotherapy, radiotherapy and radical. The purpose of this study was to review the literature on the main oral tissue complications arising from chemotherapy and radiation therapy in the head and neck region.

A Simplified Approach for Evaluation and Management of Thyroid Incidentalomas

Review Article   Open Access
The incidence of thyroid nodules has become exceedingly common seen in as many as one in seven adults owing to the increased detection through routine imaging studies. These are called incidental thyroid nodules or incidentalomas, many of which are occult differentiated micro carcinomas.

Elucidating the Role of Malnutrition in Acute Leukemia Patients and How it Leads to Adverse Events During Hospitalization: An Interesting Study

Research Article   Open Access
Malnutrition negatively impacts patients with hematologic malignancies and is considered a poor marker and indicator of prognosis. Our study explored the association between malnutrition and patients hospitalized with acute leukemia, including patients with both acute myeloid and acute lymphocytic leukemia.

Comparative Analysis of Enteral and Parenteral Nutrition Impact on Outcomes in Esophageal Cancer Patients: A Paradigm for Nutritional Optimization in Oncology

Research Article   Open Access
Individuals diagnosed with esophageal cancer face a pronounced risk of malnutrition, primarily attributed to the early onset of gastrointestinal obstruction. This risk persists and may even intensify following therapeutic interventions and the subsequent reconstruction of gastrointestinal passages. The current study focuses on elucidating the differential impact of enteral vs. parenteral nutrition on outcomes in patients hospitalized with esophageal cancer.

Revealing the Correlation Between Multiple Myeloma and Frailty: Contemporary Perspectives and In-Depth Insights

Research Article   Open Access
The research sought to assess the association between frailty and hospitalized individuals with a diagnosis of multiple myeloma. The National Inpatient Sample database for 2019-2020 was queried to identify individuals over 18 years diagnosed with multiple myeloma, utilizing the appropriate ICD-10 codes.

Hepatocellular Carcinoma with Portal Vein Thrombus has Achieved Complete Remission by Hepatic Arterial Infusion Chemotherapy Combined with Anti-PD-1 Therapy: A Case Report

Case Report   Open Access
A 56-year-old female was diagnosed with advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) in December 15, 2021. Half a month after oral sorafenib treatment, the patient experienced hematemesis and systemic rash reactions and was admitted to our hospital. An abdominal MRI revealed an 8.6 cm mass in the right lobe of the liver with PVTT.

Resection of a Gastroblastoma in an Adult Patient: An Unsuspected and Unusual Tumor

Case Report   Open Access
Since the first description of gastroblastoma in 2009, 19 cases have been previously reported, most of them in young adults and children. The prognosis is uncertain, however, malignant tumors have been described. A female patient, 44-years-old was studied with upper endoscopy and abdominal tomography for an incidentally found, submucosal tumor of the gastric antrum.

Empowering Oncologists to Successfully Address Non-Medical Opioid Use During Cancer Treatment: A Review of Best Practices

Review Article   Open Access
Non-medical opioid use (NMOU), opioid use disorder (OUD) and substance use disorders (SUD) in patients with cancer present an ongoing and growing challenge to the teams caring for them, especially their most trusted partners, oncologists.

Adult Intradural Extramedullary Ewing's Sarcoma of the Lumbar Spine and Involving the Intervertebral Foramen: A Case Report

Case Report   Open Access
Spinal intradural extramedullary Ewing's sarcoma (IEES) is very rare. Here, we report an adult IEES located in the lumbar spine and involving the intervertebral foramen. A 45-year-old gentleman presented with a one-month history of low back pain. The magnetic resonance imaging (MRI) and computed tomography (CT) showed occupation of the spinal canal and right intervertebral foramen at L4-5 levels.

The Effects of Calcium Channel Blocker Combined with Oxaliplatin on Apoptosis of Bladder Cancer Cells

Research Article   Open Access
This experiment explores the effect of calcium ion (Ca2+) on oxaliplatin-induced bladder cancer cell apoptosis and investigates the impact of blocking calcium channels on oxaliplatin-induced bladder cancer cell apoptosis. Bladder cancer cells were cultured in vitro.

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